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Abstract
Myeongsu Joa,1, Choongjin Band,1, Kelvin K.T. Gohe,*, Young Jin Choia,b,c,*
aDepartment of Agricultural Biotechnology, Republic of Korea
bCenter for Food and Bioconvergence, Republic of Korea
cResearch Institute of Agriculture and Life Sciences, Seoul National University, 1 Gwanakro, Gwanakgu, Seoul, 08826, Republic of Korea
dDepartment of Environmental Horticulture, University of Seoul, 163 Seoulsiripdaero, Dongdaemun-gu, Seoul, 02504, Republic of Korea
eSchool of Food and Advanced Technology, Massey University, Private Bag 11 222, Palmerston North, 4442, New Zealand
1These authors contributed equally to this work.
*Corresponding author
Abstract
To enhance its gut health-promoting activity and bioaccessibility, resveratrol was loaded in emulsions stabilized by octenyl succinic anhydride-modified waxy maize starch nanocrystals and then coated with chitosan. Resveratrol loaded in >0.1% chitosan-coated emulsions adhered more robustly onto porcine intestinal mucosa than did resveratrol powder (23-fold) and chitosan-uncoated emulsions (7-fold). Unlike chitosan-uncoated emulsions, chitosan-coated emulsions were stable during gastric digestion and slowly hydrolyzed in a small intestinal environment. After in vitro digestion, > 90% of the soluble fractions of resveratrol loaded in chitosan-coated and chitosan-uncoated emulsions were 14-fold greater than that of resveratrol powder. The findings suggest that the chitosan-coating enhances both the gut-retention time of resveratrol and its bioaccessibility, resulting in prolonged bioactivity of non-oxidized resveratrol. Moreover, the colloidal stability of resveratrol-loaded and chitosan-coated emulsions was maintained for 2 months (pH 4; 25 °C). This study provides useful information to guide development of an effective oral delivery system for resveratrol.
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