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레벨5
Daegu*
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16.06.07 17:31
A dose in grams benzathine penicillin will result in penicillinaemia due to over accumulation. International units are well defined in case of penicillin as other antibiotics are given on any particular day during the week after injection, ambulant adult males were injected with 2 400 000 IU of ”all-purpose” penicillin (600 000 IU potassium penicillin G, 600 000 IU procaine penicillin G and 1 200 000 IU of benzathine penicillin. benzathine penicillin is a long lasting component has an extremely low solubility and the drug is slowly released from IM injection sites (blood levels persist from 4 to 14 days depending on dose). T max is 4 h (procaine IM). Penicillin G–sensitive is highly sensitive to microorganisms that are susceptible to the low and very prolonged serum levels common to this dose form in man. All penicillins are ineffective toward cell wall-deficient microorganisms such as Mycoplasma or Chlamydia spp. International unit of penicillin is the specific penicillin activity 0.6 microgram of sodium salt. of penicillin G. Thus 1 mg pure penicillin G sodium equals 1667 units, 1 mg pure penicillin G potassium equals 1595 units. its 400, 000 units are equal to (250 mg), The dosage of synthetic penicillin is expressed in terms of weight given in mg/body weight, while natural prescription is always provided in internation units.
https://www.researchgate.net/post/Why_does_Penicillin_concentration_is_given_in_Units_and_not_micro_grams_per_mL