한빛사 논문
Abstract
Yu Shun Tian, Dr.2, Hyang Yeon Lee 1, Chang Su Lim 2, Jongmin Park 1, Hwan Myung Kim, Prof. Dr. 3, Yoo Na Shin 2, Eun Sun Kim, Dr. 4, Hoon Jae Jeon, Prof. Dr. 4, Seung Bum Park, Prof. Dr. 1 *, Bong Rae Cho, Prof. Dr. 2 *
1Department of Chemistry, Seoul National University, Seoul 151-747 (Korea), Fax: (+82) 2-884-4025
2Department of Chemistry, Korea University, 1-Anamdong, Seoul 136-701 (Korea), Fax: (+82) 2-3290-3544
3Department of Chemistry, Ajou University (Korea)
4School of Medicine, Korea University
*Correspondence to Seung Bum Park, 1Department of Chemistry, Seoul National University, Seoul 151-747 (Korea), Fax: (+82) 2-884-4025
*Correspondence to Bong Rae Cho, 2Department of Chemistry, Korea University, 1-Anamdong, Seoul 136-701 (Korea), Fax: (+82) 2-3290-3544
†This work was partly supported by a Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea Ministry of Education, Science, and Technology (MESF) (grant no.: R0A-2007-000-20027-0), the WCU program through the KOSEF funded by the MESF, and the MarineBio Technology Program funded by the Ministry of Land, Transport, and Maritime Affairs (MLTM), Korea. H.Y.L. and J.P. received BK21 Scholarships and Seoul Science Fellowships.
Funded by:
Korea Science and Engineering Foundation (KOSEF)
Korea Ministry of Education, Science, and Technology (MESF); Grant Number: R0A-2007-000-20027-0
Ministry of Land, Transport, and Maritime Affairs (MLTM), Korea
Keywords
antitumor agents, fluorescent probes, glucose, imaging agents, two-photon microscopy
Abstract
It takes two: Two-photon tracers (AG1, AG2) have been developed that can be excited by 780 nm fs laser pulses, can be easily loaded into cancer cells and tissues, show high photostability and negligible toxicity, and can visualize glucose uptake in living cells and tissues by two-photon microscopy (TPM). Moreover, AG2 can screen anticancer agents in cancer cells and cancer tissues at 75-150 mm depth by TPM.
Received: 3 March 2009; Revised: 4 August 2009
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