한빛사 논문
Abstract
Hyung Joong Kim1,‡, Ji Hee Han2,‡, Mi Kyung Kim1, Chang Su Lim2, Prof. Hwan Myung Kim1, Prof. Bong Rae Cho2
1Division of Energy Systems Research, Ajou University, Suwon, 443-749 (Korea), Fax: (+82)31-219-1615
2Department of Chemistry, Korea University, 1-Anamdong, Seoul, 136-701 (Korea), Fax: (+82) 2-3290-3544
†This work was supported by the National Research Foundation (NRF) grants funded by the Korean Government (No. 2009-0065783 and 2009-0083078) and Priority Research Centers Program through the NRF funded by the Ministry of Education, Science, and Technology (2009-0093826).
‡These two authors contributed equally to this work.
A two-photon probe (BCaM) shows 14-fold enhancement in two-photon emission fluorescence in response to Ca2+ and shows high sensitivity and selectivity for near-membrane Ca2+ ions (see picture). Combined with the known Na+ two-photon probe ANa1, BCaM allows simultaneous dual-color imaging of Ca2+/Na+ activities within live cells and in tissues at more than 100 μm depth for long time periods without photobleaching.
Keywords
calcium;fluorescence spectroscopy;imaging agents;live tissue;two-photon microscopy
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