한빛사 논문
Abstract
Taekhoon Kim1,‡, Eun-Jin Cho4,5,‡, Youngjoo Chae1, Minsik Kim1, Aram Oh1, Juhong Jin1, Eun-Sook Lee2,5, Dr. Hionsuck Baik6, Prof. Seungjoo Haam7, Prof. Jin-Suck Suh2,5, Prof. Yong-Min Huh2,3,5,*, Prof. Kwangyeol Lee1,*
1Department of Chemistry, Korea University, Seoul 136-701 (Korea)
2YUHS-KRIBB Medical Convergence Research Institute, Yonsei University, Seoul 120-752 (Korea)
3Severance Biomedical Science Institute, Yonsei University (Korea)
4Program for Nanomedical Science and Technology, Yonsei University (Korea)
5Department of Radiology & Department of Biochemistry and, Molecular Biology, Yonsei University (Korea)
6Korea Basic Science Institute (KBSI), Seoul 136-713 (Korea)
7Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749 (Korea)
Email: Prof. Yong-Min Huh, Prof. Kwangyeol Lee
*Correspondence: Prof. Kwangyeol Lee, Department of Chemistry, Korea University, Seoul 136-701 (Korea)
*Correspondence: Prof. Yong-Min Huh, YUHS-KRIBB Medical Convergence Research Institute, Yonsei University, Seoul 120-752 (Korea)
Image enhancement: Core-shell MnO@Mn3O4 urchin-shaped nanoparticles can be synthesized by means of an anisotropic etching process and used as a pH-activatable T1 contrast agent for magnetic resonance imaging. The manganese ions released from the MnO phase in the low-pH sites within tumor cells lead to an enhanced T1 contrast image for the entire tumor mass.
Keywords:anisotropic etching;crystal growth;magnetic resonance imaging;manganese;nanoparticles
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