한빛사 논문
Abstract
Dr. Hee Jung Park1,‡, Chang Su Lim1,‡, Prof. Dr. Eun Sun Kim2, Ji Hee Han1, Tae Hee Lee3, Prof. Dr. Hoon Jai Chun2, Prof. Dr. Bong Rae Cho1,*
1Department of Chemistry, Korea University, 145, Anam-ro, Sungbuk-gu, Seoul, 136-713 (Korea)
2School of Medicine, Korea University (Korea)
3Department of Chemistry, Chungnam National University (Korea)
‡ These authors contributed equally to this work.
*Correspondence : Department of Chemistry, Korea University, 145, Anam-ro, Sungbuk-gu, Seoul, 136-713 (Korea)
†This work was supported by grants from the Korea Healthcare Technology R&D Project, the Ministry of Health & Welfare, the Republic of Korea (A111182), and the NRF (No. 2011-0020477).
pH values go live! A ratiometric two-photon (TP) probe (NP1, see scheme) that has a significant TP action cross-section, high photostability, negligible toxicity, and can estimate pH values in live cells and human tissues by two-photon microscopy is described. NP1 can detect the difference in pH between live cells from the gastroesophageal junction (GEJ) and the lower esophageal sphincter of patients with and without esophagitis (see image).
Keywords:fluorescent probes;imaging agents;live-cell imaging;naphthalenes;two-photon microscopy
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