한빛사 논문
Abstract
Nohyun Lee†,§, Yoonseok Choi‡,§, Youjin Lee†, Mihyun Park†, Woo Kyung Moon‡, Seung Hong Choi*,‡, and Taeghwan Hyeon*,†
† World Class University Program of Chemical Convergence for Energy and Environment, Institute of Chemical Processes, and School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-744, Korea
‡ Diagnostic Radiology, Seoul National University Hospital, and the Institute of Radiation Medicine, Medical Research Center, Seoul National University, 28, Yeongeon-dong, Jongno-gu, Seoul, 110-744, Korea
§ Author Contributions
These authors contributed equally to this work.
Abstract
The theoretically predicted maximum r2 relaxivity of iron oxide nanoparticles was achieved by optimizing the overall size of ferrimagnetic iron oxide nanocubes. Uniform-sized iron oxide nanocubes with an edge length of 22 nm, encapsulated with PEG-phospholipids (WFION), exhibited high colloidal stability in aqueous media. In addition, WFIONs are biocompatible and did not affect cell viability at concentrations up to 0.75 mg Fe/ml. Owing to the enhanced colloidal stability and the high r2 relaxivity (761 mM-1 s-1), it was possible to successfully perform in vivo MR imaging of tumors by intravenous injection of 22-nm-sized WFIONs, using a clinical 3-T MR scanner.
Keywords: Nanoparticle; nanomedicine; iron oxide; magnetic resonance imaging; contrast agent; colloidal stability
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