한빛사 논문
Sang Cheon Leea, Il Keun Kwona, Kinam Parka, b, *
a Kyung Hee University, School of Dentistry, Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology, Seoul, Korea
b Purdue University, Departments of Biomedical Engineering & Pharmaceutics, West Lafayette, IN, USA
*Corresponding author at: Kinam Park, Purdue University, Departments of Biomedical Engineering & Pharmaceutics, 206 S. Martin Jischke Drive, West Lafayette, IN 47907, USA.
Abstract
Since 1960 when the history of modern hydrogels began significant progresses have been made in the field of controlled drug delivery. In particular, recent advances in the so-called smart hydrogels have made it possible to design highly sophisticated formulations, e.g., self-regulated drug delivery systems. Despite intensive efforts, clinical applications of smart hydrogels have been limited. Smart hydrogels need to be even smarter to execute functions necessary for achieving desired clinical functions. It is necessary to develop novel hydrogels that meet the requirements of the intended, specific applications, rather than finding applications of newly developed hydrogels. Furthermore, developing smarter hydrogels that can mimic natural systems is necessary, but the fundamental differences between natural and synthetic systems need to be understood. Such understanding will allow us to develop novel hydrogels with new, multiple functions we are looking for.
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