한빛사 논문
Abstract
Wooram Park†, Sin-Jung Park‡, Soojeong Cho†, Heejun Shin‡, Young-Seok Jung‡, Byeongdu Lee*∥, Kun Na*‡, and Dong-Hyun Kim*†§
†Department of Radiology, Feinberg School of Medicine and §Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, United States
‡ Center for Photomedicine, Department of Biotechnology, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 14662, Republic of Korea
∥ X-ray Science Division, Argonne National Laboratory, Argonne, Illinois 60439, United States
*Corresponding Authors
Abstract
We developed a thermoswitchable polymeric photosensitizer (T-PPS) by conjugating PS (Pheophorbide-a, PPb-a) to a temperature-responsive polymer backbone of biocompatible hydroxypropyl cellulose. Self-quenched PS molecules linked in close proximity by π-π stacking in T-PPS were easily transited to an active monomeric state by the temperature-induced phase transition of polymer backbones. The temperature-responsive intermolecular interaction changes of PS molecules in T-PPS were demonstrated in synchrotron small-angle X-ray scattering and UV?vis spectrophotometer analysis. The T-PPS allowed switchable activation and synergistically enhanced cancer cell killing effect at the hyperthermia temperature (45 °C). Our developed T-PPS has the considerable potential not only as a new class of photomedicine in clinics but also as a biosensor based on temperature responsiveness.
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