한빛사 논문
Zhen Jin,†,‡ Kim Tien Nguyen,†,‡ Gwangjun Go,†,‡ Byungjeon Kang,† Hyun-Ki Min,† Seok-Jae Kim,† Yun Kim,§ Hao Li,† Chang-Sei Kim,†,‡ Seonmin Lee,∥ Sukho Park,*,⊥ Kyu-Pyo Kim,*,∥ Kang Moo Huh,*,# Jihwan Song,*,§ Jong-Oh Park,*,†,‡ and Eunpyo Choi*,†,‡
† Korea Institute of Medical Microrobotics, 43-26 Cheomdangwagi-ro, Buk-gu, Gwangju 61011, Republic of Korea
‡ School of Mechanical Engineering, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Republic of Korea
§ Department of Mechanical Engineering, Hanbat National University, Deongmyeong-dong, Yuseong-gu, Daejeon 34158, Republic of Korea
∥ Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-Gu, Seoul 05505, Republic of Korea
⊥ Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Republic of Korea
# Department of Polymer Science and Engineering, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Republic of Korea
Author Contributions
Z.J., K.T.N., and G.G. contributed equally to this work.
*Corresponding Authors
Abstract
Nanorobots are safe and exhibit powerful functionalities, including delivery, therapy, and diagnosis. Therefore, they are in high demand for the development of new cancer therapies. Although many studies have contributed to the progressive development of the nanorobot system for anticancer drug delivery, these systems still face some critical limitations, such as potentially toxic materials in the nanorobots, unreasonable sizes for passive targeting, and the lack of several essential functions of the nanorobot for anticancer drug delivery including sensing, active targeting, controlling drug release, and sufficient drug loading capacity. Here, we developed a multifunctional nanorobot system capable of precise magnetic control, sufficient drug loading for chemotherapy, light-triggered controlled drug release, light absorption for photothermal therapy, enhanced magnetic resonance imaging, and tumor sensing. The developed nanorobot system exhibits an in vitro synergetic antitumor effect of photothermal therapy and chemotherapy and outstanding tumor-targeting efficiency in both in vitro and in vivo environments. The results of this study encourage further explorations of an efficient active drug delivery system for cancer treatment and the development of nanorobot systems for other biomedical applications.
KEYWORDS : Nanorobot system, active tumor targeting, controlled drug release, chemo-photothermal therapy, cancer treatment
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