한빛사 논문
인하대학교
Kyu-Sun Lee,1,* Byung-Sup Lee,2,* Sahar Semnani,3,* Agnesa Avanesian,3 Chae-Yoon Um,4 Hyun-Jin Jeon,4 Ki-Moon Seong,5 Kweon Yu,1 Kyung-Jin Min,2,**,# and Mahtab Jafari3,**,#
1Aging Research Center, Korean Research Institute of Bioscience and Biotechnology, Daejeon, Korea.
2Department of Biological Sciences, Inha University Incheon, Korea.
3Department of Pharmaceutical Sciences, University of California, Irvine, California.
4Insan Daejin High School, Goyang, Korea.
5Division of Radiation Effect Research, Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd., Seoul, Korea.
*These authors contributed equally as first authors.
**These authors contributed equally as senior authors.
#Corresponding author
Abstract
Background: Curcumin, an extract from the rhizome of the plant Curcuma longa (turmeric), has been widely used as a spice and herbal medicine in Asia. It has been suggested to have many biological activities, such as antioxidative, antiinflammatory, anticancer, chemopreventive, and antineurodegenerative properties. We evaluated the impact of curcumin on life span, fecundity, feeding rate, oxidative stress, locomotion, and gene expression in two different wild-type Drosophila melanogaster strains, Canton-S and Ives, under two different experimental conditions.
Results: We report that curcumin extended the life span of two different strains of D. melanogaster, an effect that was accompanied by protection against oxidative stress, improvement in locomotion, and chemopreventive effects. Life span extension was gender and genotype specific. Curcumin also modulated the expression of several aging-related genes, including mth, thor, InR, and JNK.
Conclusions: The observed positive effects of curcumin on life span and health span in two different D. melanogaster strains demonstrate a potential applicability of curcumin treatment in mammals. The ability of curcumin to mitigate the expression levels of age-associated genes in young flies suggests that the action of curcumin on these genes is a cause, rather than an effect, of its life span–extending effects.
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