한빛사 논문
Sang Ihn Hana,b, Sang‐woo Leec, Min Gee Choa,b, Ji Mun Yooa,b, Myoung Hwan Oha,b, Beomgyun Jeongd, Dokyoon Kime, Ok Kyu Parka,b, Junchul Kimc, Eun Namkoongc, Jinwoung Joa,b, Nohyun Leef, Chaehong Lima,b, Min Soha,b, Yung‐Eun Sunga,b, Jongman Yoog, Kyungpyo Parkc,*, Taeghwan Hyeona,b,*
aCenter for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 08826, Republic of Korea
bSchool of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea
cDepartment of Physiology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul 03080, Republic of Korea
dAdvanced Nano Surface Research Group, Korea Basic Science Institute, Daejeon 34133, Republic of Korea
eDepartment of Bionano Engineering and Bionanotechnology, Hanyang University, Ansan 15588, Republic of Korea
fSchool of Advanced Materials Engineering, Kookmin University, Seoul 136-702, Republic of Korea
gDepartment of Microbiology, School of Medicine, CHA University, Sungnam 13488, Republic of Korea
S.I.H., S.-w.L., and M.G.C. contributed equally to this work.
*To whom correspondence should be addressed.
Abstract
Nanomaterials with antioxidant properties are promising for treating reactive oxygen species (ROS)‐related diseases. However, maintaining efficacy at low doses to minimize toxicity is a critical for clinical applications. Tuning the surface strain of metallic nanoparticles can enhance catalytic reactivity, which has rarely been demonstrated in metal oxide nanomaterials. Here, it is shown that inducing surface strains of CeO2/Mn3O4 nanocrystals produces highly catalytic antioxidants that can protect tissue‐resident stem cells from irradiation‐induced ROS damage. Manganese ions deposited on the surface of cerium oxide (CeO2) nanocrystals form strained layers of manganese oxide (Mn3O4) islands, increasing the number of oxygen vacancies. CeO2/Mn3O4 nanocrystals show better catalytic activity than CeO2 or Mn3O4 alone and can protect the regenerative capabilities of intestinal stem cells in an organoid model after a lethal dose of irradiation. A small amount of the nanocrystals prevents acute radiation syndrome and increases the survival rate of mice treated with a lethal dose of total body irradiation.
논문정보
TOP52020년 후보
관련 링크
연구자 키워드
관련분야 연구자보기
관련분야 논문보기