한빛사 논문
Bo Yu1, Bongseo Choi1, Weiguo Li1,2 & Dong-Hyun Kim1,2,3,4,*
1Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
2Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA.
3Robert H. Lurie Comprehensive Cancer Center, Chicago, IL 60611, USA.
4Department of Biomedical Engineering, McCormick School of Engineering, Evanston, IL 60208, USA.
*Corresponding author
Abstract
We report a strategy to boost Fenton reaction triggered by an exogenous circularly polarized magnetic field (MF) to enhance ferroptosis-like cell-death mediated immune response, as well as endow a responsive MRI capability by using a hybrid core-shell vesicles (HCSVs). HCSVs are prepared by loading ascorbic acid (AA) in the core and poly(lactic-co-glycolic acid) shell incorporating iron oxide nanocubes (IONCs). MF triggers the release of AA, resulting in the increase of ferrous ions through the redox reaction between AA and IONCs. A significant tumor suppression is achieved by Fenton reaction-mediated ferroptosis-like cell-death. The oxidative stress induced by the Fenton reaction leads to the exposure of calreticulin on tumor cells, which leads to dendritic cells maturation and the infiltration of cytotoxic T lymphocytes in tumor. Furthermore, the depletion of ferric ions during treatment enables monitoring of the Fe reaction in MRI-R2* signal change. This strategy provides a perspective on ferroptosis-based immunotherapy.
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