한빛사 논문
DaBin Yim,† Da-Eun Lee,‡ Yoonhee So,† Chanhee Choi,† Wooic Son,‡ Kiseok Jang,§ Chul-Su Yang,‡, #,* and Jong-Ho Kim†,*
† Department of Chemical Engineering, Hanyang University, Ansan 15588, Republic of Korea
‡ Department of Molecular and Life Science, Hanyang University, Ansan 15588, Republic of Korea
§ Department of Pathology, Hanyang University College of Medicine, Seoul 04763, Republic of Korea
# Department of Bionano Technology, Hanyang University, Seoul 04763, Republic of Korea
*Corresponding author
Abstract
Sepsis is an aberrant systemic inflammatory response mediated by excessive production of reactive oxygen species (ROS) and reactive nitrogen species (RNS). Developing an efficient antioxidant therapy for sepsis via scavenging ROS and RNS remains a big challenge owing to the insufficient activity and sustainability of conventional antioxidants. Herein, biocompatible transition-metal dichalcogenide antioxidants with excellent scavenging activity and sustainability for H2O2, O2•–, OH•, and nitric oxide are developed for effective sepsis treatment. WS2, MoSe2, and WSe2 nanosheets exfoliated and functionalized with a biocompatible polymer effectively scavenge mitochondrial and intracellular ROS and RNS in inflammatory cells. Among the nanosheets, WS2 most efficiently suppresses the excessive secretion of inflammatory cytokines along with scavenging ROS and RNS without affecting the expression levels of the anti-inflammatory cytokine and ROS-producing enzymes. The WS2 nanosheets significantly improve the survival rate up to 90% for severely septic mice by reducing systemic inflammation. The pharmacokinetics suggests that the WS2 nanosheets can be excreted from mice 3 days after intravenous injection. This work demonstrates the potential of therapeutic nanosheet antioxidants for effective treatment of ROS and RNS-related diseases.
KEYWORDS:nanotherapy, reactive oxygen species, reactive nitrogen species, sepsis, TMD antioxidant
논문정보
관련 링크
연구자 키워드
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기