한빛사 논문
서울대학교 의과대학
Hyo Soon An, MD, Eun Jung Bae, MD, Gi Beom Kim, MD, Bo Sang Kwon, MD, Jae Suk Beak, MD, Ee Kyung Kim, MD, Han Suk Kim, MD, Jung-Hwan Choi, MD, Chung Il Noh, MD and Yong Soo Yun, MD
Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea.
Correspondence: Eun Jung Bae, MD
Abstract
Background and Objectives
With the increasing survival of preterm infants, pulmonary hypertension (PH) related to bronchopulmonary dysplasia (BPD) has become an important complication. The aim of this study was to investigate the characteristics and outcome of PH in preterm infants with BPD and to identify the risk factors for PH.
Subjects and Methods
We reviewed the records of 116 preterm infants with BPD cared for at a single tertiary center between 2004 and 2008.
Results
Twenty-nine (25%) infants had PH >2 months after birth. PH occurred initially at a median age of 65 days (range, 7-232 days). Severe BPD, a birth weight <800 g, long-term ventilator care and oxygen supplementation, a high ventilator setting, infection, and a patent ductus arteriosus (PDA) were related to PH based on univariate analysis (p<0.05). The infants who had longer oxygen supplementation were significantly more likely to have PH (odds ratio, 18.5; 95% confidence interval, 4.1-84.6; p<0.001). PH was improved in 76% of infants after a median of 85 days (range, 20-765 days). Four infants (14%) died. The death of 3 infants was attributed to PH.
Conclusion
BPD was frequently complicated by PH. Although PH resolved in the majority of infants, PH in preterm infants with BPD can be fatal. Regular screening for PH and adequate management are required.
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