한빛사 논문
Sang-Ho Kang1,11,*, Ramesh Prasad Pandey2,9,11, Chang-Muk Lee3, Joon-Soo Sim3, Jin-Tae Jeong4, Beom-Soon Choi5, Myunghee Jung6, Daniel Ginzburg7, Kangmei Zhao7, So Youn Won1, Tae-Jin Oh2, Yeisoo Yu5,10, Nam-Hoon Kim5, Ok Ran Lee8, Tae-Ho Lee1, Puspalata Bashyal2, Tae-Su Kim2, Woo-Haeng Lee2, Charles Hawkins7, Chang-Kug Kim1, Jung Sun Kim1, Byoung Ohg Ahn1, Seung Yon Rhee7,* & Jae Kyung Sohng2,*
1Genomics Division, National Institute of Agricultural Sciences, RDA, Jeonju 54874, Republic of Korea.
2Department of Pharmaceutical Engineering and Biotechnology, Sun Moon University, Asan 31460, Republic of Korea.
3Metabolic Engineering Division, National Institute of Agricultural Sciences, RDA, Jeonju 54874, Republic of Korea.
4Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong 55365, Republic of Korea.
5Phyzen Genomics Institute, Seongnam 13488, Republic of Korea.
6Department of Forest Science, College of Agriculture and Life Science, Seoul National University, Seoul 08826, Republic of Korea.
7Department of Plant Biology, Carnegie Institution for Science, Stanford, CA 94305, USA. 8Department of Applied Plant Science, College of Agriculture and Life Science, Chonnam National University, Gwangju 61186, Republic of Korea.
9Present address: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
10Present address: DNACARE Co. Ltd, Seoul 06730, Republic of Korea.
11These authors contributed equally: Sang-Ho Kang, Ramesh Prasad Pandey.
*Corresponding author
Abstract
Senna tora is a widely used medicinal plant. Its health benefits have been attributed to the large quantity of anthraquinones, but how they are made in plants remains a mystery. To identify the genes responsible for plant anthraquinone biosynthesis, we reveal the genome sequence of S. tora at the chromosome level with 526 Mb (96%) assembled into 13 chromosomes. Comparison among related plant species shows that a chalcone synthase-like (CHS-L) gene family has lineage-specifically and rapidly expanded in S. tora. Combining genomics, transcriptomics, metabolomics, and biochemistry, we identify a CHS-L gene contributing to the biosynthesis of anthraquinones. The S. tora reference genome will accelerate the discovery of biologically active anthraquinone biosynthesis pathways in medicinal plants.
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