한빛사 논문
Jong Seob Choia,1, Heon Joon Leea,1, Swaminathan Rajaramanc,d,e, Deok-Ho Kima,b,*
aDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21205, United States
bDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, United States
cNanoScience Technology Center (NSTC), University of Central Florida, Orlando, FL, 32826-0120, United States
dDepartment of Electrical & Computer Engineering, University of Central Florida, Orlando, FL, 32816, United States
eDepartment of Materials Science & Engineering, University of Central Florida, Orlando, FL, 32816, United States
1J. S. Choi and H. J. Lee have contributed equally to this work.
*Corresponding author
Abstract
Three-dimensional microelectrode arrays (3D MEAs) have emerged as promising tools to detect electrical activities of tissues or organs in vitro and in vivo, but challenges in achieving fast, accurate, and versatile monitoring have consistently hampered further advances in analyzing cell or tissue behaviors. In this review, we discuss emerging 3D MEA technologies for in vitro recording of cardiac and neural cellular electrophysiology, as well as in vivo applications for heart and brain health diagnosis and therapeutics. We first review various forms of recent 3D MEAs for in vitro studies in context of their geometry, materials, and fabrication processes as well as recent demonstrations of 3D MEAs to monitor electromechanical behaviors of cardiomyocytes and neurons. We then present recent advances in 3D MEAs for in vivo applications to the heart and the brain for monitoring of health conditions and stimulation for therapy. A brief overview of the current challenges and future directions of 3D MEAs are provided to conclude the review.
Keywords : 3D MEAs; Cardiac interface; Neuronal interface; Cellular electrophysiology
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