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Abstract
Moon Ho Doa,1, Hye-Bin Leea,b,1, Mi-Jin Ohc, Hyunjhung Jhunc, Sang Yoon Choia, Ho-Young Parka,*
aResearch Group of Functional Food Materials, Korea Food Research Institute, Jeollabuk-do 55365, Republic of Korea
bDepartment of Food Science and Technology, Jeonbuk National University, Jeollabuk-do, 54896, Republic of Korea
cTechnical Assistance Center, Korea Food Research Institute, Jeollabuk-do 55365, Republic of Korea
1Co-first author.
*Corresponding author
Abstract
Radish (Raphanus sativus) greens are commonly used as a vegetable in Korea; however, their anti-obesity effect has not been reported yet. We prepared the polysaccharide fraction of radish greens (PRG) and assessed its anti-obesity activity in high fat diet (HFD)-induced obese C57BL/6J mice. Supplementation with 4 mg/kg PRG reduced weight gain and body fat percentage, and regulated serum biomarkers against HFD-induced obesity. Moreover, PRG treatment improved gut permeability by increasing tight junction protein expression and colon length shortening. HFD intake increased the proportion of Firmicutes and decreased the proportion of Bacteroidetes and Verrucomicrobia; however, PRG supplementation maintained gut microbial composition to normal diet condition. Moreover, PRG reduced HFD-induced increase of lipid metabolism-related protein expression, along with adipocyte size in white adipose tissue. These results indicated that PRG as a potential prebiotic, has anti-obesity properties by improving gut barrier function, modulating gut microbiota and regulating lipid metabolism.
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