한빛사 논문
Gwangjun Go1,2, Ami Yoo1, Hyeong-Woo Song1, Hyun-Ki Min1, Shirong Zheng1,2, Kim Tien Nguyen1, Seokjae Kim1, Byungjeon Kang1,3, Ayoung Hong1,3, Chang-Sei Kim1,2,*, Jong-Oh Park1,2,*, Eunpyo Choi1,2,*
1Korea Institute of Medical Microrobotics (KIMIRo), 43-26 Cheomdangwagi-ro, Buk-gu, Gwangju, 61011, Korea
2School of Mechanical Engineering, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju, 61186, Korea
3College of AI convergence, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju, 61186, Korea
*Corresponding author
Abstract
We described a magnetic chitosan microscaffold tailored for applications requiring high biocompatibility, biodegradability, and monitoring by real-time imaging. Such magnetic microscaffolds exhibit adjustable pores and sizes depending on the target application and provide various functions such as magnetic actuation and enhanced cell adhesion using biomaterial-based magnetic particles. Subsequently, we fabricated the magnetic chitosan microscaffolds with optimized shape and pore properties to specific target diseases. As a versatile tool, the capability of the developed microscaffold was demonstrated through in vitro laboratory tasks and in vivo therapeutic applications for liver cancer therapy and knee cartilage regeneration. We anticipate that the optimal design and fabrication of the presented microscaffold will advance the technology of biopolymer-based microscaffolds and micro/nanorobots.
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