한빛사 논문
숙명여자대학교
Mi-Young PARK,1 Hoon-Jeong KWON,2 and Mi-Kyung SUNG1*
1Department of Food and Nutrition, Sookmyung Women’s University, Seoul, 140-742, Korea 2Department of Food and Nutrition, Seoul National University, Seoul, 151-742, Korea
*Corresponding author
Abstract
The aloe ingredients responsible for physiological effects and the concentrations required to exert their biological activities are not fully understood. This study compares the anti-inflammatory effects of aloin and aloe-emodin with other polyphenols. Our results demonstrated that aloe-emodin dose-dependently inhibited inducible nitric oxide synthase (iNOS) mRNA expression and nitric oxide (NO) production at 5–40 μM. In addition, the levels of cyclooxygenase-2 (COX-2) mRNA and prostaglandin E2 (PGE2) production were suppressed by 40 μM aloe-emodin. Aloin also suppressed the production of NO at 5–40 μM, although it did not suppress PGE2 production. The present results indicate that aloin and aloe-emodin possibly suppress the inflammatory responses by blocking iNOS and COX-2 mRNA expression. The anti-inflammatory effect of aloe-emodin was comparable to that of kaempferol and quercetin, indicating aloe-emodin as a possible key constituent responsible for the anti-inflammatory activity of aloe.
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