한빛사 논문
Grace Egan1, Dilshad H. Khan2, Jong Bok Lee2, Sara Mirali3, Li Zhang4 and Aaron D Schimmer5,*
1Haematology Oncology, Princess Margaret Cancer Centre
2University of Toronto
3Institute of Medical Science, University of Toronto
4Toronto General Research Institute, University Health Network
5Princess Margaret Cancer Centre
*Corresponding Author
Abstract
Mitochondria are involved in many biological processes including cellular homeostasis, energy generation and apoptosis. Moreover, mitochondrial and metabolic pathways are interconnected with gene expression to regulate cellular functions such as cell growth, survival, differentiation and immune recognition. Metabolites and mitochondrial enzymes regulate chromatin modifying-enzymes, chromatin remodeling, and transcription regulators. Deregulation of mitochondrial pathways and metabolism leads to alterations in gene expression that promotes cancer development, progression and evasion of the immune system. This review highlights how mitochondrial and metabolic pathways function as a central mediator to control gene expression, specifically on stem cell functions, differentiation and immune response in leukemia.
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