한빛사 논문
Yeon Sik Choi 1,2,3,24, Rose T. Yin 4,24, Anna Pfenniger5,24, Jahyun Koo1,2,24, Raudel Avila6, K. Benjamin Lee7, Sheena W. Chen7, Geumbee Lee1,2,3, Gang Li8, Yun Qiao4, Alejandro Murillo-Berlioz9, Alexi Kiss10,11, Shuling Han12,13, Seung Min Lee1, Chenhang Li 6, Zhaoqian Xie 14, Yu-Yu Chen15, Amy Burrell5, Beth Geist5, Hyoyoung Jeong 1,2, Joohee Kim 1,2, Hong-Joon Yoon1,2,3,16, Anthony Banks1,2, Seung-Kyun Kang17,18, Zheng Jenny Zhang 12,13, Chad R. Haney 19,20, Alan Varteres Sahakian19,21, David Johnson5, Tatiana Efimova10,11, Yonggang Huang1,3,6,22, Gregory D. Trachiotis9, Bradley P. Knight5, Rishi K. Arora5,*, Igor R. Efimov4,* and John A. Rogers1,2,3,6,19,23,*
1Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL, USA. 2Querrey Simpson Institute for Biotechnology, Northwestern University, Evanston, IL, USA. 3Department of Materials Science and Engineering, Northwestern University, Evanston, IL, USA. 4Department of Biomedical Engineering, The George Washington University, Washington, DC, USA. 5Feinberg School of Medicine, Cardiology, Northwestern University, Chicago, IL, USA. 6Department of Mechanical Engineering, Northwestern University, Evanston, IL, USA. 7Department of Surgery, The George Washington University, Washington, DC, USA. 8Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, MO, USA. 9Department of Cardiothoracic Surgery, Veteran Affairs Medical Center, Washington, DC, USA. 10Department of Anatomy and Cell Biology, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA. 11The George Washington Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA. 12Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. 13Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. 14State Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, International Research Center for Computational Mechanics, Dalian University of Technology, Dalian, China. 15Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA. 16School of Advanced Materials Science and Engineering, Sungkyunkwan University, Suwon, Republic of Korea. 17Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA. 18Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA. 19Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA. 20Center for Advanced Molecular Imaging, Northwestern University, Evanston, IL, USA. 21Department of Electrical and Computer Engineering, Northwestern University, Evanston, IL, USA. 22Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL, USA. 23Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. 24These authors contributed equally: Yeon Sik Choi, Rose T. Yin, Anna Pfenniger and Jahyun Koo.
*Corresponding authors
Abstract
Temporary cardiac pacemakers used in periods of need during surgical recovery involve percutaneous leads and externalized hardware that carry risks of infection, constrain patient mobility and may damage the heart during lead removal. Here we report a leadless, battery-free, fully implantable cardiac pacemaker for postoperative control of cardiac rate and rhythm that undergoes complete dissolution and clearance by natural biological processes after a defined operating timeframe. We show that these devices provide effective pacing of hearts of various sizes in mouse, rat, rabbit, canine and human cardiac models, with tailored geometries and operation timescales, powered by wireless energy transfer. This approach overcomes key disadvantages of traditional temporary pacing devices and may serve as the basis for the next generation of postoperative temporary pacing technology.
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