한빛사 논문
Oju Jeona, Yu Bin Leea, Sang Jin Leea, Nazilya Guliyevaa, Joanna Leeb, Eben Alsberga,c,d,e,*
aDepartment of Biomedical Engineering, University of Illinois at Chicago, Chicago, IL, 60607, USA
bDepartment of Chemistry, University of Illinois at Chicago, Chicago, IL, 60607, USA
cDepartment of Orthopaedics, University of Illinois at Chicago, Chicago, IL, 60607, USA
dDepartment of Pharmacology, University of Illinois at Chicago, Chicago, IL, 60607, USA
eDepartment of Mechanical and Industrial Engineering, University of Illinois at Chicago, Chicago, IL, 60607, USA
*Corresponding author
Abstract
Recently, 3D bioprinting has been explored as a promising technology for biomedical applications with the potential to create complex structures with precise features. Cell encapsulated hydrogels composed of materials such as gelatin, collagen, hyaluronic acid, alginate and polyethylene glycol have been widely used as bioinks for 3D bioprinting. However, since most hydrogel-based bioinks may not allow rapid stabilization immediately after 3D bioprinting, achieving high resolution and fidelity to the intended architecture is a common challenge in 3D bioprinting of hydrogels. In this study, we have utilized shear-thinning and self-healing ionically crosslinked oxidized and methacrylated alginates (OMAs) as a bioink, which can be rapidly gelled by its self-healing property after bioprinting and further stabilized via secondary crosslinking. It was successfully demonstrated that stem cell-laden calcium-crosslinked OMA hydrogels can be bioprinted into complicated 3D tissue structures with both high resolution and fidelity. Additional photocrosslinking enables long-term culture of 3D bioprinted constructs for formation of functional tissue by differentiation of encapsulated human mesenchymal stem cells.
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