한빛사 논문
Suk-Min Hong1,2,3,#, Ji-Young Yoon1,2,5,11,#, Jae-Ryung Cha1,2,3,#, Junyong Ahn1,2,4,5, Nandin Mandakhbayar1,2,5, Jeong Hui Park1,5, Junseop Im7, Gangshi Jin1,2,5, Moon-Young Kim1,5,8, Jonathan C. Knowles2,5,9,10, Hae-Hyoung Lee1,2,4,5, Jung-Hwan Lee1,2,4,5,6*, Hae-Won Kim1,2,4,5,6*
1Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, Chungcheognam-do, 31116, Republic of Korea
2Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, Chungcheognam-do, 31116, Republic of Korea
3Department of Chemistry, College of Science and Technology, Dankook University, Cheonan, Chungcheognam-do, 31116, Republic of Korea
4Department of Biomaterials Science, College of Dentistry, Dankook University, Cheonan, Chungcheognam-do, 31116, Republic of Korea
5UCL Eastman-Korea Dental Medicine Innovation Centre, Dankook University, Cheonan, Chungcheognam-do, 31116, Republic of Korea
6Cell & Matter Institute, Dankook University, Cheonan, Chungcheongnam-do, 31116, South Korea.
7Samyang Corporation, 730 Daeduck-daero, Yuseong-gu, Daejeon, 34055, South Korea
8Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University, 119 Dandae-ro, Cheonan, Chungcheongnam-do 31116, Republic of Korea
9Division of Biomaterials and Tissue Engineering, Eastman Dental Institute, Royal Free Hospital, Rowland Hill Street, London, NW3 2PF, UK
10The Discoveries Centre for Regenerative and Precision Medicine, Eastman Dental Institute, University College London, London, UK
11TCell & Matter Corporation, Cheonan, Chungcheongnam-do, 31116, South Korea.
#These authors contributed equally to this work.
*Corresponding authors
Abstract
Novel polycaprolactone-based polyurethane (PCL-PU) copolymers with hyperelasticity, shape-memory, and ultra-cell-adhesion properties are reported as clinically applicable tissue-regenerative biomaterials. New isosorbide derivatives (propoxylated or ethoxylated ones) were developed to improve mechanical properties by enhanced reactivity in copolymer synthesis compared to the original isosorbide. Optimized PCL-PU with propoxylated isosorbide exhibited notable mechanical performance (50 MPa tensile strength and 1150% elongation with hyperelasticity under cyclic load). The shape-memory effect was also revealed in different forms (film, thread, and 3D scaffold) with 40%–80% recovery in tension or compression mode after plastic deformation. The ultra-cell-adhesive property was proven in various cell types which were reasoned to involve the heat shock protein-mediated integrin (α5 and αV) activation, as analyzed by RNA sequencing and inhibition tests. After the tissue regenerative potential (muscle and bone) was confirmed by the myogenic and osteogenic responses in vitro, biodegradability, compatible in vivo tissue response, and healing capacity were investigated with in vivo shape-memorable behavior. The currently exploited PCL-PU, with its multifunctional (hyperelastic, shape-memorable, ultra-cell-adhesive, and degradable) nature and biocompatibility, is considered a potential tissue-regenerative biomaterial, especially for minimally invasive surgery that requires small incisions to approach large defects with excellent regeneration capacity.
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