한빛사 논문
Ryul Kim 1, Han-Joon Kim 2*, Jung Hwan Shin 2, Chan Young Lee 3, Seung Ho Jeon 4, Beomseok Jeon 2
1Department of Neurology, Inha University Hospital, Inha University College of Medicine, Incheon, South Korea.
2Department of Neurology and Movement Disorder Center, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
3Department of Neurology, School of Medicine, Ewha Womans University Mokdong Hospital, Seoul, South Korea.
4Eco Fineday Neurology Clinic, Jeonju, South Korea.
*Corresponding author.
Abstract
Background
The influence of peripheral inflammation on nonmotor symptoms (NMSs) in Parkinson's disease (PD) remains unclear.
Objective
The aim of this study was to explore whether serum inflammatory marker profiles are associated with the progression of NMSs in early PD.
Methods
We included 45 patients with early PD and 20 healthy control subjects. Six inflammatory markers, including interleukin (IL)-1β, IL-2, IL-6, IL-10, tumor necrosis factor-α, and high-sensitivity C-reactive protein, were measured. NMSs were assessed using the Non-Motor Symptoms Scale, Montreal Cognitive Assessment, and Composite Autonomic Symptom Score-31 at baseline and after 3 years.
Results
Principal component (PC) analysis showed that only PC3 scores, mainly loaded by IL-2 and IL-6, were significantly elevated in the PD group compared with the control group. Higher PC3 scores in the PD group were associated with faster progression of Non-Motor Symptoms Scale total and mood/apathy domain scores. There were no significant associations of PC scores with Montreal Cognitive Assessment and Composite Autonomic Symptom Score-31 score changes.
Conclusions
Peripheral inflammation may be related to the evolution of NMSs, particularly mood symptoms, in the early stages of PD.
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