한빛사 논문
Sangsoo Han1, Jiwon Park2, Hae-Dong Jang3, Sangun Nah1, Joonhyeok Boo2, Kyungdo Han4* & Jae-Young Hong2*
1Department of Emergency Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea; 2Department of Orthopedics, Korea University Hospital, Ansan-si, Gyeonggi-do, Republic of Korea; 3Department of Orthopaedic Surgery, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea; 4Department of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of Korea
*Correspondence
Sangsoo Han and Jiwon Park contributed equally to this study as co-first authors.
Kyungdo Han and Jae-Young Hong contributed equally to this study as co-corresponding authors.
Abstract
Background
Hip fracture is a major public health problem worldwide and being underweight is a risk factor for fractures. Few studies have investigated the association between being underweight and hip fracture in the general population. The present study investigated the incidence of hip fracture in a large population cohort based on detailed information about the degree of underweight.
Methods
A nationwide retrospective cohort study of adults ≥40 years of age included 962,533 subjects who were not overweight or obese in 2009. The incidence and risk of hip fracture occurring between 2010 and 2018 was assessed based on the degree of underweight. Based on body mass index (BMI), the study population was categorized into normal (18.50–22.99 kg/m2), mild (17.00–18.49 kg/m2), moderate (16.00–16.99 kg/m2), and severe underweight (<16.00 kg/m2) groups. Cox proportional hazards analyses were performed to calculate the hazard ratio (HR) for the hip fracture based on the degree of underweight in reference to the normal weight.
Results
Compared with subjects who were normal weight, those who were classified as mild underweight (1.03/1000 person-years (PY) increase in incidence rate (IR); adjusted HR (aHR) 1.61; 95% confidence interval (CI) 1.48–1.76), moderate underweight (2.04/1000 PY increase in IR; aHR 1.85; 95% CI 1.65–2.08), or severe underweight (4.58/1000 PY increase in IR; aHR 2.33; 95% CI 2.03–2.66) were at significantly increased risk of hip fracture.
Conclusions
The severity of underweight was significantly associated with risk of hip fracture. The subdivision of underweight helps to estimate fracture risk more accurately.
논문정보
관련 링크
연구자 키워드
연구자 ID
관련분야 연구자보기
관련분야 논문보기
해당논문 저자보기