한빛사 논문
Hyunjun Choi, Bongseo Choi, Jun-Hyeok Han, Ha Eun Shin, Wooram Park, and Dong-Hyun Kim*
H. Choi, B. Choi, D.-H. Kim
Department of Radiology Feinberg School of Medicine Northwestern University Chicago, IL 60611, USA
H. Choi, D.-H. Kim
Department of Biomedical Engineering University of Illinois at Chicago Chicago, IL 60607, USA
J.-H. Han, H. E. Shin, W. Park
Department of Integrative Biotechnology, College of Biotechnology and Bioengineering Sungkyunkwan UniversitySeoburo 2066, Suwon, Gyeonggi 16419, Republic of Korea
W. Park
Department of Biomedical Engineering McCormick School of Engineering Evanston, IL 60208, USA
D.-H. Kim
Robert H. Lurie Comprehensive Cancer CenterChicago, IL 60611, USA
H.C. and B.C. contributed equally to this work.
*Corresponding author.
Abstract
A reactive oxygen species (ROS) responsive cleavable hierarchical metallic supra-nanostructure (HMSN) is reported. HMSN structured with thin branches composed of primary gold (Au) nanocrystals and silver (Ag) nano-linkers is synthesized by a one-pot aqueous synthesis with a selected ratio of Au/Ag/cholate. ROS responsive degradability of HMSN is tested in the presence of endogenous and exogeneous ROS. Significant ROS-responsive structural deformation of HMSN is observed in the ROS exposure with hydrogen peroxide (H2O2) solution. The ROS responsiveness of HMSN is significantly comparable with negligible structural changes of conventional spherical gold nanoparticles. The demonstrated ROS responsive degradation of HMSN is further confirmed in various in vitro ROS conditions of each cellular endogenous ROS and exogeneous ROS generated by photodynamic therapy (PDT) or X-ray radiation. Then, in vivo ROS responsive degradability of HMSN is further evaluated with intratumoral injection of HMSN and exogeneous ROS generation via PDT in a mouse tumor model. Additional in vivo biodistribution and toxicity of intravenously administrated HMSN at 30-day post-injection are investigated for potential in vivo applications. The observed ROS responsive degradability of HMSN will provide a promising option for a type of ROS responsive-multifunctional nanocarriers in cancer treatment and various biomedical applications.
논문정보
관련 링크
연구자 키워드
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기