한빛사 논문
Joo Y. Lee1,* and Daniel H. Hwang2
1 Department of Life Science, Gwangju Institute of Science and Technology, Gwangju 500-712, Korea;
2 USDA, ARS, Western Human Nutrition Research Center, and Department of Nutrition, University of California, Davis, CA 95616,
USA.
* To whom correspondence should be addressed. : Joo Y. Lee
Abstract
Toll-like receptors (TLRs) were evolved to detect invading pathogens and to induce innate immune responses in order to mount host defense mechanisms. It becomes apparent that the activation of certain TLRs is also modulated by endogenous molecules including lipid components, fatty acids. Results from epidemiological and animal studies demonstrated that saturated and polyunsaturated dietary fatty acids can differentially modify the risk of development of many chronic diseases. Inflammation is now recognized as an important underlying etiologic condition for the pathogenesis of many chronic diseases. Therefore, if the activation of TLRs and consequent inflammatory and immune responses are differentially modulated by types of lipids in vivo, this would suggest that the risk of the development of chronic inflammatory diseases and the host defense against microbial infection may be modified by the types of dietary fat consumed.
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