연구용제품시약 > Antibody
[BioXCell Korea] InVivoPlus anti-mouse PD-L1 (B7-H1) Clone: 10F.9G2
바이오엑스셀코리아
BioXCell 은(www.bxcell.com) (www.bxcell.co.kr)
In Vivo용 Antibody를 1mg,5mg,25mg,50mg,100mg
용량으로 직접 제조하며, 합리적인 가격으로
공급하는 회사입니다.
▶약 300여종의 제품을 보유(Mouse, Human, Rat ..)
▶high quality
▶bulk quantity (milligram to gram)
▶low endotoxin levels
▶well suited for in-vivo preclinical studies.
Our InVivoPlus™ antibodies feature all the great qualities of our InVivoMab™ antibodies.
The InVivoPlus™ versions of our products are structurally and functionally identical to the InVivoMab™ versions with the added benefit of additional QC measures.
InVivoPlus™ antibodies are screened for murine pathogens using ultrasensitive qPCR, screened for protein aggregation via dynamic light scattering, feature advanced binding validation via flow cytometry, ELISA, and/or Western blot, and are guaranteed to contain less than 1 endotoxin unit per milligram.
Our InVivoPlus™ line of antibodies are designed to exceed the strict demands and rigorous standards required for in vivo work at any research organization.
Clone : 10F.9G2
Catalog# : BP0101
The 10F.9G2 monoclonal antibody reacts with mouse PD-L1 (programmed death ligand 1) also known as B7-H1 or CD274. PD-L1 is a 40 kDa type I transmembrane protein that belongs to the B7 family of the Ig superfamily.
PD-L1 is expressed on T lymphocytes, B lymphocytes, NK cells, dendritic cells, as well as IFNγ stimulated monocytes, epithelial cells and endothelial cells. PD-L1 binds to its receptor, PD-1, found on CD4 and CD8 thymocytes as well as activated T and B lymphocytes and myeloid cells. Engagement of PD-L1 with PD-1 leads to inhibition of TCR-mediated T cell proliferation and cytokine production.
PD-L1 is thought to play an important role in tumor immune evasion. Induced PD-L1 expression is common in many tumors and results in increased resistance of tumor cells to CD8 T cell mediated lysis.
In mouse models of melanoma, tumor growth can be transiently arrested via treatment with antibodies which block the interaction between PD-L1 and PD-1. The 10F.9G2 antibody has been shown to block the interaction between PD-L1 and PD-1 and between PD-L1 and B7-1 (CD80).
Isotype | Rat IgG2b, κ |
Recommended Isotype Control(s) | InVivoPlus™ rat IgG2b isotype control, anti-keyhole limpet hemocyanin |
Recommended Dilution Buffer | InVivoPure™ pH 6.5 Dilution Buffer |
Immunogen | Mouse CD274 |
Reported Applications |
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Formulation |
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*Endotoxin |
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*Aggregation |
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Purity |
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Sterility | 0.2 μM filtered |
Production | Purified from tissue culture supernatant in an animal free facility |
Purification | Protein G |
RRID | AB_10949073 |
Molecular Weight | 150 kDa |
*Murine Pathogen Test Results |
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Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
자세한 문의사항은 본사로 문의해 주시기 바랍니다.
(BioXCell Korea는 BioClone의 자회사 입니다)
바이오엑스셀 코리아 (www.bxcell.co.kr)
Tel : 02)2013-8240 Fax : 02)2013-8243
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