한빛사 논문
Young Min Son1,2, In Su Cheon1,2, Yue Wu1,2, Chaofan Li1,2, Zheng Wang1,2, Xiaochen Gao1,2, Yao Chen3, Yoshimasa Takahashi4, Yang-Xin Fu5, Alexander L. Dent6, Mark H. Kaplan6, Justin J. Taylor7, Weiguo Cui3,8 and Jie Sun1,2,*
1Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
2Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
3Versiti Blood Research Institute, Milwaukee, WI 53213, USA.
4Department of Immunology, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo 162-8640, Japan.
5Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75235, USA.
6Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
7Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
8Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
*Corresponding author.
Abstract
Much remains unknown about the roles of CD4+ T helper cells in shaping localized memory B cell and CD8+ T cell immunity in the mucosal tissues. Here, we report that lung T helper cells provide local assistance for the optimal development of tissue-resident memory B and CD8+ T cells after the resolution of primary influenza virus infection. We have identified a population of T cells in the lung that exhibit characteristics of both follicular T helper and TRM cells, and we have termed these cells as resident helper T (TRH) cells. Optimal TRH cell formation was dependent on transcription factors involved in T follicular helper and resident memory T cell development including BCL6 and Bhlhe40. We show that TRH cells deliver local help to CD8+ T cells through IL-21–dependent mechanisms. Our data have uncovered the presence of a tissue-resident helper T cell population in the lung that plays a critical role in promoting the development of protective B cell and CD8+ T cell responses.
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