한빛사 논문
Keumyeon Kim1,2,*, Ji Hyun Ryu3,*, Mi-Young Koh2,*, Sung Pil Yun4, Soomi Kim2, Joseph P. Park1, Chul-Woo Jung5, Moon Sue Lee2, Hyung-Il Seo4,†, Jae Hun Kim4,† and Haeshin Lee1,2,†
1Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
2R&D Center, InnoTherapy Inc., Seoul, Republic of Korea.
3Department of Carbon Convergence Engineering, Wonkwang University, Iksan, Jeonbuk, Republic of Korea.
4Department of Surgery, Pusan National University Hospital, Busan, Republic of Korea.
5Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
†Corresponding author.
*These authors contributed equally to this work.
Abstract
Since the first report of underwater adhesive proteins of marine mussels in 1981, numerous studies have reported mussel-inspired synthetic adhesive polymers. However, none of them have developed up to human-level translational studies. Here, we report a sticky polysaccharide that effectively promotes hemostasis from animal bleeding models to first-in-human hepatectomy. We found that the hemostatic material instantly generates a barrier layer that seals hemorrhaging sites. The barrier is created within a few seconds by in situ interactions with abundant plasma proteins. Therefore, as long as patient blood contains proper levels of plasma proteins, hemostasis should always occur even in coagulopathic conditions. To date, insufficient tools have been developed to arrest coagulopathic bleedings originated from genetic disorders, chronic diseases, or surgical settings such as organ transplantations. Mussel-inspired adhesion chemistry described here provides a useful alternative to the use of fibrin glues up to a human-level biomedical application.
논문정보
관련 링크
연구자 키워드
연구자 ID
관련분야 연구자보기
관련분야 논문보기