한빛사 논문
Bong Hwan Sung1, Carole A. Parent2,3,4,5, Alissa M. Weaver1,6,7,*
1Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, 1161 Medical Center Dr, Nashville, TN 37232, USA
2Department of Pharmacology, University of Michigan, 500 S. State Street, Ann Arbor, MI 48109, USA
3Department of Cell and Developmental Biology, University of Michigan, 500 S. State Street, Ann Arbor, MI 48109, USA
4Rogel Cancer Center, University of Michigan, 500 S. State Street, Ann Arbor, MI 48109, USA
5Life Sciences Institute, University of Michigan, 500 S. State Street, Ann Arbor, MI 48109, USA
6Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, 1211 Medical Center Dr, Nashville, TN 37232, USA
7Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, 2220 Pierce Ave, Nashville, TN 37232, USA
*Corresponding author
Abstract
Cell migration is essential for the development and maintenance of multicellular organisms, contributing to embryogenesis, wound healing, immune response, and other critical processes. It is also involved in the pathogenesis of many diseases, including immune deficiency disorders and cancer metastasis. Recently, extracellular vesicles (EVs) have been shown to play important roles in cell migration. Here, we review recent studies describing the functions of EVs in multiple aspects of cell motility, including directional sensing, cell adhesion, extracellular matrix (ECM) degradation, and leader-follower behavior. We also discuss the role of EVs in migration during development and disease and the utility of imaging tools for studying the role of EVs in cell migration.
Keywords : extracellular vesicles, exosomes, microvesicles, migrasomes, cell migration, cell motility, chemotaxis, live imaging, adhesion
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