한빛사 논문
Dong-Yeon Kim1,2,14, Ayoung Pyo3,4,14, Sehyeon Ji5, Sung-Hwan You2,6, Seong Eun Kim5, Daejin Lim7, Heejung Kim8, Kyung-Hwa Lee9, Se-Jeong Oh10, Ye-rim Jung3,6, Uh Jin Kim5, Subin Jeon3, Seong Young Kwon3,6, Sae-Ryung Kang3,6, Hyang Burm Lee11, Hoon Hyun12, So-Young Kim2,6, Kyung-Sub Moon10, Sunwoo Lee13, Seung Ji Kang5,* & Jung-Joon Min2,3,6,*
1College of Pharmacy and Research Institute of Pharmaceutical Science, Gyeongsang National University, Jinju, Korea. 2CNCure Biotech, Hwasun, Korea. 3Innovation Center for Molecular Probe Development, Department of Nuclear Medicine, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Korea. 4Accelerator & RI Development Team, Korea Atomic Energy Research Institute, Jeongeup, Korea. 5Department of Internal Medicine, Chonnam National University Medical School, Hwasun, Korea. 6Institute for Molecular Imaging and Theranostics, Chonnam National University Medical School, Hwasun, Korea. 7Division of Biomedical Convergence, College of Biomedical Science, Kangwon National University, Chuncheon, Korea. 8Korea Radioisotope Center for Pharmaceuticals, Korea Institute of Radiological & Medical Sciences, Seoul, Korea. 9Department of Pathology, Chonnam National University Medical School, Hwasun, Korea. 10Department of Neurosurgery, Chonnam National University Medical School, Hwasun, Korea. 11Department of Agricultural Biological Chemistry, Chonnam National University, Gwangju, Korea. 12Department of Biomedical Sciences, Chonnam National University Medical School, Hwasun, Korea. 13Department of Chemistry, Chonnam National University, Gwangju, Korea. 14These authors contributed equally: Dong-Yeon Kim, Ayoung Pyo.
*Corresponding author.
Abstract
Invasive aspergillosis is a critical complication in immunocompromised patients with hematologic malignancies or with viral pneumonia caused by influenza virus or SARS‑CoV‑2. Although early and accurate diagnosis of invasive aspergillosis can maximize clinical outcomes, current diagnostic methods are time-consuming and poorly sensitive. Here, we assess the ability of 2-deoxy-2-18F-fluorosorbitol (18F-FDS) positron emission tomography (PET) to specifically and noninvasively detect Aspergillus infections. We show that 18F-FDS PET can be used to visualize Aspergillus fumigatus infection of the lungs, brain, and muscles in mouse models. In particular, 18F-FDS can distinguish pulmonary aspergillosis from Staphylococcus aureus infection, both of which induce pulmonary infiltrates in immunocompromised patients. Thus, our results indicate that the combination of 18F-FDS PET and appropriate clinical information may be useful in the differential diagnosis and localization of invasive aspergillosis.
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