한빛사 논문
Jae Chul Hwang1,2†, Moohyun Kim1,2†, Sumin Kim1,2, Hunkyu Seo1,2, Soohwan An2,3, Eui Hwa Jang4, Seung Yeop Han2,3, Mi Jung Kim1,5, Nam Kyun Kim4, Seung-Woo Cho2,3*, Sak Lee4*, Jang-Ung Park1,2,5*
1Department of Materials Science and Engineering, Yonsei University, Seoul 03722, Republic of Korea.
2Center for Nanomedicine, Institute for Basic Science (IBS), Yonsei University, Seoul 03722, Republic of Korea.
3Department of Biotechnology, Yonsei University, Seoul 03722, Republic of Korea.
4Division of Cardiovascular Surgery, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Yonsei University Health System, Seoul 03722, Republic of Korea.
5KIURI Institute, Yonsei University, Seoul 03722, Republic of Korea.
†These authors contributed equally to this work.
*Corresponding author. Email: Seung-Woo Cho, Sak Lee, Jang-Ung Park
Abstract
The in situ diagnosis of cardiac activities with simultaneous therapeutic electrical stimulation of the heart is key to preventing cardiac arrhythmia. Here, we present an unconventional single-device platform that enables in situ monitoring even in a wet condition and control of beating heart motions without interferences to the recording signal. This platform consists of the active-matrix array of pressure-sensitive transistors for detecting cardiac beatings, biocompatible, low-impedance electrodes for cardiac stimulations, and an alginate-based hydrogel adhesive for attaching this platform conformally to the epicardium. In contrast to conventional electrophysiological sensing using electrodes, the pressure-sensitive transistors measured mechanophysiological characteristics by monitoring the spatiotemporal distributions of cardiac pressures during heart beating motions. In vivo tests show mechanophysiological readings having good correlation with electrocardiography and negligible interference with the electrical artifacts caused during cardiac stimulations. This platform can therapeutically synchronize the rhythm of abnormal heartbeats through efficient pacing of cardiac arrhythmia.
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